ICP-332: An Oral TYK2-JH1 Inhibitor,
A Potential Blockbuster
ICP-332 is a potent and highly selective TYK2 inhibitor that can effectively block TYK2.
TYK2 is a member of the JAK kinase family, which is an important kinase on the JAK-STAT signaling pathway, playing an
important role in the pathogenesis of T-cell inflammatory diseases.

• Phase I data demonstrated a dose proportional and
favorable PK profile, no observation of significant food
effect, and a well-tolerated safety profile.

• Patient enrollment of the Phase II trial of ICP-332 for the treatment of atopic dermatitis (AD) was completed with a data readout expected by the end of 2023.

• According to the source of Pharma Intelligence, AD has
become a major autoimmune disease with a global
market potential of US$10 billion by 2030.

ICP-488: A Potential Blockbuster
as an Oral TYK2-JH2 Inhibitor
ICP-488 is a potent and highly selective TYK2 allosteric inhibitor. By binding the TYK2-JH2 domain, ICP-488 blocks the
signal transduction of IL-23, IL-12, type 1 IFN and other inflammatory cytokines, thereby inhibiting the pathological
process of autoimmune and inflammatory diseases.

• InnoCare is accelerating the ongoing Phase I study of
ICP-488 with psoriasis patients, and preliminary PoC is
expected by the last quarter of 2023. The Phase II study
for psoriasis is in preparation.

• In Phase I clinical trial with healthy subjects, the single
ascending doses (SAD) and multiple ascending doses
(MAD) have been completed with ICP-488,
demonstrating a well-tolerated safety profile.

• Compared with other JAK family inhibitors, ICP-332 has a potential significant advantage in safety.